MicroRNAs in Bladder Outlet Obstruction: Relationship to Growth and Matrix Remodelling
نویسندگان
چکیده
منابع مشابه
MicroRNAs in Bladder Outlet Obstruction: Relationship to Growth and Matrix Remodelling.
The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biological functions of miRNAs in the lower urog...
متن کاملBladder outlet obstruction due to labial agglutination.
Here, we report the case of a 63-year-old female patient who presented with emptying symptoms and was subsequently diagnosed with delayed labial agglutination. The adhered labia minora were divided by blunt dissection, and a topical estrogen ointment was applied after surgery. The patient's voiding symptoms were completely resolved and no recurrence of labial agglutination was noted 3 months af...
متن کاملEXPERIENCE WITH BLADDER NECK INCISION TO RELIEVE BLADDER OUTLET OBSTRUCTION VERSUS TRANSURETHRAL RESECTION OF THE PROSTATE IN SHIRAZ
TUR is cited as the treatment of choice for relief of bladder outflow tract obstruction in the male, but bladder neck incision (BNI) is an acceptable alternative when the gland is smalI.1,2,3 Sixty cases of BNIfTUR have been reviewed (BNI=35, TUR=25) from March, 1986 to April, 1988. BNI was done when the glands were less than 30 gr , and when there was no clinical suspicion of malignancy t...
متن کاملMir-29 Repression in Bladder Outlet Obstruction Contributes to Matrix Remodeling and Altered Stiffness
Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower urinary tract and increases bladder stiffness. Here we tested the hypothesis that miR-29 is repressed in the bladder in outlet obstruction and that...
متن کاملBladder outlet obstruction in painful bladder syndrome/interstitial cystitis.
AIMS Obstructive symptoms such as slow stream, dribbling and straining are often reported by painful bladder syndrome and interstitial cystitis (PBS/IC) patients. Our hypothesis was that some patients with PBS/IC have an associated measurable bladder outlet obstruction (BOO) secondary to dysfunctional voiding and that those patients with more severe PBS/IC are more likely to have BOO. METHODS...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2016
ISSN: 1742-7835
DOI: 10.1111/bcpt.12534